Decursinol

Animal and in vitro experiments suggest the ability of Decursinol-50™ extract, and the major components decursinol and decursin, to alleviate minor pain. Decursinol, one of the compounds purified from the dried roots of Angelica gigas Nakai, has been studied in animals for its pain relieving effects. It appears to possess analgesic effects in animal studies by impacting opioid receptors in the central nervous system, but may also affect adrenergic and serotonergic receptors. The central nervous system effect seems to be the major mechanism of action of the product. Decursin, a related but distinct compound from Angelica gigas Nakai, has shown modulatory activities on a number of degradation enzymes and cytokines of the immune system in vitro.